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Leckman JF, Ort S, Caruso KA, et al "Rebound phenomena in Tourette's syndrome after abrupt withdrawal of clonidine: behavioral, cardiovascular, and neurochemical effects.
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However, personnel supervising in this setting should possess assessment abilities and be able to summon help through the emergency medical system.
Hospitalized patients will need a thorough history and physical exam.
Behavioral therapy, contingency management and a depot formulation havebeen proposed as approaches to enhance medication compliance and retention.
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Use of opiates (commonly prescribed methadone or illicit heroin) by pregnant women may result in a withdrawal syndrome in their newborn infants.
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Therapeutic doses of amphetamine also enhance cortical network efficiency, an effect which mediates improvements in working memory in all individuals.
Thus far no well-controlled studies have been conducted to provide guidelines as to when these medications should be introduced during detoxification or whether it would be better to wait until the early phase of rehabilitation.
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For patients who clearly need the structure of a methadone program, but prefer buprenorphine, it could be dispensed by a methadone program using the same rules as methadone.
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The most frequent (which also appear to be dose-related) are dry mouth (approximately 40%); drowsiness (approximately 33%; dizziness (approximately 16%); constipation and sedation (approximately 10% each).
Mechanism of Analgesia Clonidine attenuates the opioid withdrawal syndrome.
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